Hapatra, Vizier of Poisons + Yawgmoth, Thran Physician + Blood Artist

Prerequisites

• You control at least one additional creature.
• Your life total is at least 2.
• An opponent controls a creature.

Steps

1. 1Activate Yawgmoth by paying 1 life and sacrificing a creature, targeting any creature an opponent controls.
2. 2The sacrificed creature dies, triggering Blood Artist, causing an opponent to lose 1 life and you to gain 1 life.
3. 3Resolve the Yawgmoth ability, putting a -1/-1 counter on a creature an opponent controls, and causing you to draw a card.
4. 4Hapatra's second ability triggers, creating a 1/1 Snake creature token.
5. 5Repeat.
6. 6You may also repeat this loop whenever a creature enters the battlefield under an opponent's control.

Effects

• Destroy all creatures opponents control
• Destroy each creature that enters the battlefield under an opponent's control
• Infinite -1/-1 counters
• Lock
• Near-infinite card draw
• Near-infinite death triggers
• Near-infinite draw triggers
• Near-infinite ETB
• Near-infinite lifegain triggers
• Near-infinite lifeloss
• Near-infinite LTB
• Near-infinite sacrifice triggers