Pox Plague + Archfiend of Despair

Prerequisites

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Steps

1. 1Cast Pox Plague by paying , causing each player to lose half their life, discard half their hand, and sacrifice half their permanents, rounded down. Ensure that you don't sacrifice Archfiend of Despair.
2. 2At the beginning of your end step, Archfiend of Despair triggers, causing each opponent to lose life equal to the life they've lost this turn.

Effects

• Near-infinite lifeloss for all players